Sustainable FDI for sustainable development

Based on an examination of 150 instruments (ranging from international investment agreements to MNE codes) that deal with the interaction between host countries and MNEs, this Perspective identifies common FDI sustainability characteristics and suggests ways in which stakeholders can utilize and promote them, including in the context of investment facilitation

Effectiveness of Varenicline as an Aid to Smoking Cessation in Primary Care: An Observational Study

Aims: Although varenicline is commonly prescribed in primary care, information on smoking-related comorbidities and the effectiveness of varenicline in this context in Germany is scarce. This study assessed the efficacy and safety of varenicline in a large sample of patients seeking smoking cessation treatment through their general practitioners. The frequency of comorbidities was also evaluated. Methods: This was a 12-week, prospective, observational, non-comparative phase IV trial conducted in Germany. Abstinence rates at week 12 were evaluated by verbal reporting using the nicotine use inventory. Results: Overall, 1,391 subjects were enrolled; 1,177 received study medication and were evaluated for effectiveness and safety. At the end of the study, 71.1% (95% confidence interval 68.5–73.7) of subjects were abstinent. There were a total of 205 all-causality adverse events; 2.2% were classified as serious or severe. There were no fatal adverse events. At inclusion, 66.7% of participants had at least 1 concurrent comorbidity, with chronic obstructive pulmonary disease (35.5%), hypertension (29.6%) and depression (10.4%) being the most commonly reported. Conclusion: These real-world data indicate that varenicline is an effective and well-tolerated smoking cessation treatment when used in the primary care setting including patients with smoking-related comorbidities

Disulfiram, an Option for the Treatment of Pathological Gambling?

Aim: Pathological gambling and comorbid alcohol dependence often occur in combination. Disulfiram is one of the proven drugs for alcohol dependence. In addition to its inhibiting acetaldehyde dehydrogenase, disulfiram inhibits dopamine β-hydroxylase and may thereby increase dopamine and decrease norepinephrine cerebral concentrations. Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling. Method: We describe the outcome of a patient with alcohol dependence and pathological gambling treated with disulfiram D. Results: During treatment with disulfiram, the patient reported that his desire to gamble disappeared entirely. Follow-up indicated that he has not gambled for >12 months. Conclusions: Although uncontrolled case observations should be interpreted with caution, disulfiram deserves further investigation in pathological gamblin

AAT Imaging and Microslit Spectroscopy in the Southern Hubble Deep Field

We present a deep photometric (B- and R-band) catalog and an associated spectroscopic redshift survey conducted in the vicinity of the Hubble Deep Field South. The spectroscopy yields 53 extragalactic redshifts in the range 0<z<1.4 substantially increasing the body of spectroscopic work in this field to over 200 objects. The targets are selected from deep AAT prime focus images complete to R<24 and spectroscopy is 50% complete at R=23. There is now strong evidence for a rich cluster at z\simeq 0.58 flanking the WFPC2 field which is consistent with a known absorber of the bright QSO in this field. We find that photometric redshifts of z<1 galaxies in this field based on HST data are accurate to \sigma_z/(1+z)=0.03 (albeit with small number statistics). The observations were carried out as a community service for Hubble Deep Field science, to demonstrate the first use of the `nod & shuffle' technique with a classical multi-object spectrograph and to test the use of `microslits' for ultra-high multiplex observations along with a new VPH grism and deep-depletion CCD. The reduction of this new type of data is also described.Comment: From the better late than never department: AJ in press (2006). 16 pages, 2 tables, 6 figures, final data release + Appendix at http://www.aao.gov.au/hdfs/Redshifts

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1

The exceptionally conserved metazoan MAB21 proteins are implicated in cell fate decisions and share considerable sequence homology with the cyclic GMP-AMP synthase. cGAS is the major innate immune sensor for cytosolic DNA and produces the second messenger 2'-5', 3'-5' cyclic GMP-AMP. Little is known about the structure and biochemical function of other proteins of the cGAS-MAB21 subfamily, such as MAB21L1, MAB21L2 and MAB21L3. We have determined the crystal structure of human full-length MAB21L1. Our analysis reveals high structural conservation between MAB21L1 and cGAS but also uncovers important differences. Although monomeric in solution, MAB21L1 forms a highly symmetric double-pentameric oligomer in the crystal, raising the possibility that oligomerization could be a feature of MAB21L1. In the crystal, MAB21L1 is in an inactive conformation requiring a conformational change - similar to cGAS - to develop any nucleotidyltransferase activity. Co-crystallization with NTP identified a putative ligand binding site of MAB21 proteins that corresponds to the DNA binding site of cGAS. Finally, we offer a structure-based explanation for the effects of MAB21L2 mutations in patients with eye malformations. The underlying residues participate in fold-stabilizing interaction networks and mutations destabilize the protein. In summary, we provide a first structural framework for MAB21 proteins

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1

The exceptionally conserved metazoan MAB21 proteins are implicated in cell fate decisions and share considerable sequence homology with the cyclic GMP-AMP synthase. cGAS is the major innate immune sensor for cytosolic DNA and produces the second messenger 2'-5', 3'-5' cyclic GMP-AMP. Little is known about the structure and biochemical function of other proteins of the cGAS-MAB21 subfamily, such as MAB21L1, MAB21L2 and MAB21L3. We have determined the crystal structure of human full-length MAB21L1. Our analysis reveals high structural conservation between MAB21L1 and cGAS but also uncovers important differences. Although monomeric in solution, MAB21L1 forms a highly symmetric double-pentameric oligomer in the crystal, raising the possibility that oligomerization could be a feature of MAB21L1. In the crystal, MAB21L1 is in an inactive conformation requiring a conformational change - similar to cGAS - to develop any nucleotidyltransferase activity. Co-crystallization with NTP identified a putative ligand binding site of MAB21 proteins that corresponds to the DNA binding site of cGAS. Finally, we offer a structure-based explanation for the effects of MAB21L2 mutations in patients with eye malformations. The underlying residues participate in fold-stabilizing interaction networks and mutations destabilize the protein. In summary, we provide a first structural framework for MAB21 proteins

Towards an Indicative List of FDI Sustainability Characteristics

Based on a review of 150 instruments, ranging from international investment agreements to codes of multinational enterprises, this paper identifies ten core characteristics of sustainable FDI and twenty emerging sustainable FDI characteristics widely accepted across ten stakeholder groups. The paper explores furthermore opportunities and mechanisms to advance the application of the sustainability characteristics. The FDI sustainability characteristics are also of immediate relevance for the discussions of investment facilitation